PART I: MINIMUM QUALITY THRESHOLD IN PRE-CLINICAL SEPSIS STUDIES (MQTiPSS) FOR STUDY DESIGN AND HUMANE MODELING ENDPOINTS.

Pre-clinical animal studies are mandatory before new treatments can be tested in clinical trials. However, their use in developing new therapies for sepsis has been controversial because of limitations of the models and inconsistencies with the clinical conditions. In consideration of the revised de...

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Detalhes bibliográficos
Publicado no:Shock
Main Authors: Zingarelli, Basilia, Coopersmith, Craig M., Drechsler, Susanne, Efron, Philip, Marshall, John C., Moldawer, Lyle, Wiersinga, W. Joost, Xiao, Xianzhong, Osuchowski, Marcin F., Thiemermann, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296871/
https://ncbi.nlm.nih.gov/pubmed/30106874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001243
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