HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-based PET Imaging

PURPOSE: Recent studies have highlighted a role of human epidermal growth factor receptor 3 (HER3) in HER2-driven cancers (e.g. breast cancer) implicating the up-regulation of the receptor in resistance to HER-targeted therapies and Hsp90 inhibitors (e.g. AUY922). Therefore, we have developed an aff...

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Publicat a:Clin Cancer Res
Autors principals: Martins, Carlos D., Da Pieve, Chiara, Burley, Thomas A., Smith, Rhodri, Ciobota, Daniela M., Allott, Louis, Harrington, Kevin J., Oyen, Wim J.G., Smith, Graham, Kramer-Marek, Gabriela
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296444/
https://ncbi.nlm.nih.gov/pubmed/29437790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2754
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