Neuroprotective effects of fatty acid amide hydrolase catabolic enzyme inhibition in a HIV-1 Tat model of neuroAIDS

The HIV-1 transactivator of transcription (Tat) is a neurotoxin involved in the pathogenesis of HIV-1 associated neurocognitive disorders (HAND). The neurotoxic effects of Tat are mediated directly via AMPA/NMDA receptor activity and indirectly through neuroinflammatory signaling in glia. Emerging s...

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Publicado no:Neuropharmacology
Main Authors: Hermes, Douglas J., Xu, Changqing, Poklis, Justin L., Niphakis, Micah J., Cravatt, Benjamin F., Mackie, Ken, Lichtman, Aron H., Ignatowska-Jankowska, Bogna M., Fitting, Sylvia
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296377/
https://ncbi.nlm.nih.gov/pubmed/30114402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2018.08.013
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