CAGE Binds to Beclin1, Regulates Autophagic Flux and CAGE-Derived Peptide Confers Sensitivity to Anti-cancer Drugs in Non-small Cell Lung Cancer Cells

The objective of this study was to determine the role of CAGE, a cancer/testis antigen, in resistance of non-small cell lung cancers to anti-cancer drugs. Erlotinib-resistant PC-9 cells (PC-9/ER) with EGFR mutations (ex 19 del + T790M of EGFR), showed higher level of autophagic flux than parental se...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Yeon, Minjeong, Byun, Jaewhan, Kim, Hyuna, Kim, Misun, Jung, Hyun Suk, Jeon, Doyong, Kim, Youngmi, Jeoung, Dooil
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296237/
https://ncbi.nlm.nih.gov/pubmed/30619741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00599
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