Human cardiac fibroblast extracellular matrix remodeling: dual effects of tissue inhibitor of metalloproteinase-2

OBJECTIVE: Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix metalloproteinases (MMPs) that attenuates maladaptive cardiac remodeling in ischemic heart failure. We examined the effects of TIMP-2 on human cardiac fibroblast activation and extracellular matrix (ECM)...

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Vydáno v:Cardiovasc Pathol
Hlavní autoři: Ngu, Janet M.C., Teng, Guoqi, Christopher Meijndert, Hans, Mewhort, Holly E., Turnbull, Jeannine D., Stetler-Stevenson, William G., Fedak, Paul W.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295929/
https://ncbi.nlm.nih.gov/pubmed/25060386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carpath.2014.06.003
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