Steric hindrance controls pyridine nucleotide specificity of a flavin‐dependent NADH:quinone oxidoreductase

The crystal structure of the NADH:quinone oxidoreductase PA1024 has been solved in complex with NAD(+) to 2.2 Å resolution. The nicotinamide C4 is 3.6 Å from the FMN N5 atom, with a suitable orientation for facile hydride transfer. NAD(+) binds in a folded conformation at the interface of the TIM‐ba...

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Udgivet i:Protein Sci
Main Authors: Ball, Jacob, Reis, Renata A. G., Agniswamy, Johnson, Weber, Irene T., Gadda, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2018
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Full‐Length Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295900/
https://ncbi.nlm.nih.gov/pubmed/30246917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3514
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