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Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe

[Image: see text] Several chemical probes have been developed for use in fluorescence polarization screening assays to aid in drug discovery for the bromodomain and extra-terminal domain (BET) proteins. However, few of those have been characterized in the literature. We have designed, synthesized, a...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Paulson, Carolyn N., Guan, Xianghong, Ayoub, Alex M., Chan, Alice, Karim, Rezaul M., Pomerantz, William C. K., Schönbrunn, Ernst, Georg, Gunda I., Hawkinson, Jon E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295860/
https://ncbi.nlm.nih.gov/pubmed/30613330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00380
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