Phase 2 Trial of Alisertib in Combination with Irinotecan and Temozolomide for Patients with Relapsed or Refractory Neuroblastoma

PURPOSE: In phase 1 testing, alisertib tablets with irinotecan and temozolomide showed significant antitumor activity in patients with neuroblastoma. The current study sought to: confirm activity of this regimen; evaluate an alisertib oral solution (OS); and evaluate biomarkers of clinical outcomes....

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Pubblicato in:Clin Cancer Res
Autori principali: DuBois, Steven G., Mosse, Yael P., Fox, Elizabeth, Kudgus, Rachel A., Reid, Joel M., McGovern, Renee, Groshen, Susan, Bagatell, Rochelle, Maris, John M., Twist, Clare J., Goldsmith, Kelly, Granger, M. Meaghan, Weiss, Brian, Park, Julie R., Macy, Margaret E., Cohn, Susan L., Yanik, Greg, Wagner, Lars, Hawkins, Randall, Courtier, Jesse, Lai, Hollie, Goodarzian, Fariba, Shimada, Hiroyuki, Boucher, Najee, Czarnecki, Scarlett, Luo, Chunqiao, Tsao-Wei, Denice D., Matthay, Katherine K., Marachelian, Araz
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295246/
https://ncbi.nlm.nih.gov/pubmed/30093449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1381
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