Methylomic analysis of ovarian cancers identifies tumor-specific alterations readily detectable in early precursor lesions

PURPOSE: High-grade serous ovarian carcinoma (HGSOC) typically remains undiagnosed until advanced stages when peritoneal dissemination has already occurred. Here, we sought to identify HGSOC-specific alterations in DNA methylation and assess their potential to provide sensitive and specific detectio...

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Dettagli Bibliografici
Pubblicato in:Clin Cancer Res
Autori principali: Pisanic, Thomas R., Cope, Leslie M., Lin, Shiou-Fu, Yen, Ting-Tai, Athamanolap, Pornpat, Asaka, Ryoichi, Nakayama, Kentaro, Fader, Amanda N., Wang, Tza-Huei, Shih, Ie-Ming, Wang, Tian-Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295225/
https://ncbi.nlm.nih.gov/pubmed/30108103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1199
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