A slow-cycling Lgr5 tumour population mediates basal cell carcinoma relapse after therapy

Basal cell carcinoma (BCC) is the most frequent cancer in humans and results from constitutive activation of the Hedgehog pathway1. Several Smoothened inhibitors (Smoi) are used to treat Hedgehog-mediated malignancies, including BCC and medulloblastoma2. Vismodegib, a Smoi, leads to BCC shrinkage in...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Sánchez-Danés, Adriana, Larsimont, Jean-Christophe, Liagre, Mélanie, Muñoz-Couselo, Eva, Lapouge, Gaëlle, Brisebarre, Audrey, Dubois, Christine, Suppa, Mariano, Sukumaran, Vijayakumar, del Marmol, Véronique, Tabernero, Josep, Blanpain, Cédric
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295195/
https://ncbi.nlm.nih.gov/pubmed/30297799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0603-3
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