A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

We combine single-cell RNA-seq and in vivo lineage tracing to study the cellular composition and hierarchy of the murine tracheal epithelium. We identify a new rare cell type, the FoxI1-positive pulmonary ionocyte; functional variations in club cells based on their proximodistal location; a distinct...

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Vydáno v:Nature
Hlavní autoři: Montoro, Daniel T., Haber, Adam L., Biton, Moshe, Vinarsky, Vladimir, Lin, Brian, Birket, Susan, Yuan, Feng, Chen, Sijia, Leung, Hui Min, Villoria, Jorge, Rogel, Noga, Burgin, Grace, Tsankov, Alexander, Waghray, Avinash, Slyper, Michal, Waldmann, Julia, Nguyen, Lan, Dionne, Danielle, Rozenblatt-Rosen, Orit, Tata, Purushothama Rao, Mou, Hongmei, Shivaraju, Manjunatha, Bihler, Hermann, Mense, Martin, Tearney, Guillermo J., Rowe, Steven M., Engelhardt, John F., Regev, Aviv, Rajagopal, Jayaraj
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295155/
https://ncbi.nlm.nih.gov/pubmed/30069044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0393-7
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