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Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

The Gam protein of transposable phage Mu is an ortholog of eukaryotic and bacterial Ku proteins, which carry out nonhomologous DNA end joining (NHEJ) with the help of dedicated ATP-dependent ligases. Many bacteria carry Gam homologs associated with either complete or defective Mu-like prophages, but...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Bhattacharyya, Sudipta, Soniat, Michael M., Walker, David, Jang, Sooin, Finkelstein, Ilya J., Harshey, Rasika M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294893/
https://ncbi.nlm.nih.gov/pubmed/30487222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816606115
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