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Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

The Gam protein of transposable phage Mu is an ortholog of eukaryotic and bacterial Ku proteins, which carry out nonhomologous DNA end joining (NHEJ) with the help of dedicated ATP-dependent ligases. Many bacteria carry Gam homologs associated with either complete or defective Mu-like prophages, but...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Bhattacharyya, Sudipta, Soniat, Michael M., Walker, David, Jang, Sooin, Finkelstein, Ilya J., Harshey, Rasika M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294893/
https://ncbi.nlm.nih.gov/pubmed/30487222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816606115
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