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Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase

The Gam protein of transposable phage Mu is an ortholog of eukaryotic and bacterial Ku proteins, which carry out nonhomologous DNA end joining (NHEJ) with the help of dedicated ATP-dependent ligases. Many bacteria carry Gam homologs associated with either complete or defective Mu-like prophages, but...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bhattacharyya, Sudipta, Soniat, Michael M., Walker, David, Jang, Sooin, Finkelstein, Ilya J., Harshey, Rasika M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294893/
https://ncbi.nlm.nih.gov/pubmed/30487222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816606115
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