Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor

Using a de novo peptide inhibitor, Corza6 (C6), we demonstrate that the human voltage-gated proton channel (hHv1) is the main pathway for H(+) efflux that allows capacitation in sperm and permits sustained reactive oxygen species (ROS) production in white blood cells (WBCs). C6 was identified by a p...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Zhao, Ruiming, Kennedy, Kelleigh, De Blas, Gerardo A., Orta, Gerardo, Pavarotti, Martín A., Arias, Rodolfo J., de la Vega-Beltrán, José Luis, Li, Qufei, Dai, Hui, Perozo, Eduardo, Mayorga, Luis S., Darszon, Alberto, Goldstein, Steve A. N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294887/
https://ncbi.nlm.nih.gov/pubmed/30478045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1816189115
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