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Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening
Familial amyloid polyneuropathy is a hereditary systemic amyloidosis caused by a mutation in the transthyretin (TTR) gene. Amyloid deposits in tissues of patients contain not only full-length TTR but also C-terminal TTR fragments. However, in vivo models to evaluate the pathogenicity of TTR fragment...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6294829/ https://ncbi.nlm.nih.gov/pubmed/30552363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36357-5 |
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