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Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening

Familial amyloid polyneuropathy is a hereditary systemic amyloidosis caused by a mutation in the transthyretin (TTR) gene. Amyloid deposits in tissues of patients contain not only full-length TTR but also C-terminal TTR fragments. However, in vivo models to evaluate the pathogenicity of TTR fragment...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Tsuda, Yukimoto, Yamanaka, Kunitoshi, Toyoshima, Risa, Ueda, Mitsuharu, Masuda, Teruaki, Misumi, Yohei, Ogura, Teru, Ando, Yukio
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294829/
https://ncbi.nlm.nih.gov/pubmed/30552363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-36357-5
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