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Legionella pneumophila inhibits immune signaling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N

The bacterial pathogen Legionella pneumophila modulates host immunity using effectors translocated by its Dot/Icm transporter to facilitate its intracellular replication. A number of these effectors employ diverse mechanisms to interfere with protein ubiquitination, a posttranslational modification...

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Udgivet i:Nat Microbiol
Main Authors: Gan, Ninghai, Nakayasu, Ernesto S., Hollenbeck, Peter J., Luo, Zhao-Qing
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294664/
https://ncbi.nlm.nih.gov/pubmed/30420781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0282-8
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