Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK)

We present the development of the first small molecule degraders that can induce anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines. These degraders were developed through conjugation...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Powell, Chelsea E., Gao, Yang, Tan, Li, Donovan, Katherine A., Nowak, Radosław P., Loehr, Amanda, Bahcall, Magda, Fischer, Eric S., Jänne, Pasi A., George, Rani E., Gray, Nathanael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294449/
https://ncbi.nlm.nih.gov/pubmed/29660984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01655
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