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Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors
[Image: see text] A series of novel 3,5-diamino-1,2,4-triazole benzyl ureas was identified as having potent anaplastic lymphoma kinase (ALK) inhibition exemplified by 15a, 20a, and 23a, which exhibited antiproliferative IC(50) values of 70, 40, and 20 nM in Tel-ALK transformed Ba/F3 cells, respectiv...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3093683/ https://ncbi.nlm.nih.gov/pubmed/21572589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200002a |
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