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Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors

[Image: see text] A series of novel 3,5-diamino-1,2,4-triazole benzyl ureas was identified as having potent anaplastic lymphoma kinase (ALK) inhibition exemplified by 15a, 20a, and 23a, which exhibited antiproliferative IC(50) values of 70, 40, and 20 nM in Tel-ALK transformed Ba/F3 cells, respectiv...

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Библиографические подробности
Главные авторы: Deng, Xianming, Wang, Jinhua, Zhang, Jianming, Sim, Taebo, Kim, Nam Doo, Sasaki, Takaaki, Luther, William, George, Rani E., Jänne, Pasi A., Gray, Nathanael S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2011
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093683/
https://ncbi.nlm.nih.gov/pubmed/21572589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200002a
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