Osteocalcin triggers Fas/FasL-mediated necroptosis in adipocytes via activation of p300

The uncarboxylated form of osteocalcin (GluOC) regulates glucose and lipid metabolism in mice. We previously showed that low-dose (≤10 ng/ml) GluOC induces the expression of adiponectin and peroxisome proliferator-activated receptor γ (PPARγ) via a cAMP–PKA–ERK–CREB signaling pathway in 3T3-L1 adipo...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Otani, Takahito, Matsuda, Miho, Mizokami, Akiko, Kitagawa, Norio, Takeuchi, Hiroshi, Jimi, Eijiro, Inai, Tetsuichiro, Hirata, Masato
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294257/
https://ncbi.nlm.nih.gov/pubmed/30546087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1257-7
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