UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice

The mechanistic target of rapamycin (mTOR) is a central regulator of cellular proliferation and metabolism. Depending on its binding partners, mTOR is at the core of 2 complexes that either promote protein biosynthesis (mTOR complex 1; mTORC1) or provide survival and proliferation signals (mTORC2)....

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Vydáno v:Blood
Hlavní autoři: Hussain, Sajjad, Bedekovics, Tibor, Liu, Qiuying, Hu, Wenqian, Jeon, Haeseung, Johnson, Sarah H., Vasmatzis, George, May, Danielle G., Roux, Kyle J., Galardy, Paul J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293873/
https://ncbi.nlm.nih.gov/pubmed/30257881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-05-848515
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