TetR-Type Regulator SLCG_2919 Is a Negative Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis

Lincomycin A (Lin-A) is a widely used antibacterial antibiotic fermented by Streptomyces lincolnensis. However, the transcriptional regulatory mechanisms underlying lincomycin biosynthesis have seldom been investigated. Here, we first identified a TetR family transcriptional regulator (TFR), SLCG_29...

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Gepubliceerd in:Appl Environ Microbiol
Hoofdauteurs: Xu, Yurong, Ke, Meilan, Li, Jie, Tang, Yaqian, Wang, Nian, Tan, Guoqing, Wang, Yansheng, Liu, Ruihua, Bai, Linquan, Zhang, Lixin, Wu, Hang, Zhang, Buchang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2018
Onderwerpen:
Genetics and Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6293104/
https://ncbi.nlm.nih.gov/pubmed/30341075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02091-18
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