TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome

KEY POINTS: The sinoatrial node (SAN) is the primary pacemaker of the heart. SAN dysfunction, or ‘sick sinus syndrome’, can cause excessively slow heart rates and pauses, leading to exercise limitation and syncope, currently treated by implantation of an electronic pacemaker. ‘Biopacemaking’ utilise...

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Vydáno v:J Physiol
Hlavní autoři: Choudhury, M., Black, N., Alghamdi, A., D'Souza, A., Wang, R., Yanni, J., Dobrzynski, H., Kingston, P. A., Zhang, H., Boyett, M. R., Morris, G. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Cardiovascular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292813/
https://ncbi.nlm.nih.gov/pubmed/30259525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276508
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