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TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

Two decades ago, the recognition of protein misfolding and aggregate accumulation as defining features of neurodegenerative disease set the stage for a thorough examination of how protein quality control is maintained in neurons and in other nonneuronal cells in the central nervous system (CNS). Aut...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Cortes, Constanza J., La Spada, Albert R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291370/
https://ncbi.nlm.nih.gov/pubmed/29852219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.05.012
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