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TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities

Two decades ago, the recognition of protein misfolding and aggregate accumulation as defining features of neurodegenerative disease set the stage for a thorough examination of how protein quality control is maintained in neurons and in other nonneuronal cells in the central nervous system (CNS). Aut...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Cortes, Constanza J., La Spada, Albert R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291370/
https://ncbi.nlm.nih.gov/pubmed/29852219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.05.012
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