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The many faces of autophagy dysfunction in Huntington's disease: from mechanistic pathways to therapeutic opportunities

Autophagy is the cellular process by which proteins, macromolecules, and organelles are targeted to and degraded by the lysosome. Given that neurodegenerative diseases involve the production of misfolded proteins that cannot be degraded by the protein quality-control systems of the cell, the autopha...

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Détails bibliographiques
Auteurs principaux: Cortes, Constanza J., La Spada, Albert R.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096219/
https://ncbi.nlm.nih.gov/pubmed/24632005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2014.02.014
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