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The many faces of autophagy dysfunction in Huntington's disease: from mechanistic pathways to therapeutic opportunities
Autophagy is the cellular process by which proteins, macromolecules, and organelles are targeted to and degraded by the lysosome. Given that neurodegenerative diseases involve the production of misfolded proteins that cannot be degraded by the protein quality-control systems of the cell, the autopha...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096219/ https://ncbi.nlm.nih.gov/pubmed/24632005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2014.02.014 |
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