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The many faces of autophagy dysfunction in Huntington's disease: from mechanistic pathways to therapeutic opportunities
Autophagy is the cellular process by which proteins, macromolecules, and organelles are targeted to and degraded by the lysosome. Given that neurodegenerative diseases involve the production of misfolded proteins that cannot be degraded by the protein quality-control systems of the cell, the autopha...
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| 主要な著者: | , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096219/ https://ncbi.nlm.nih.gov/pubmed/24632005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2014.02.014 |
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