Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity

BACKGROUND. Morbidity and mortality associated with Clostridioides (formerly Clostridium) difficile infection (CDI) rises progressively with advanced age (≥ 65 years) due in part to perturbations of the gut microbiota and immune dysfunction. Epidemiological data of community-acquired CDI suggests in...

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Veröffentlicht in:Anaerobe
Hauptverfasser: Peniche, Alex G., Spinler, Jennifer K., Boonma, Prapaporn, Savidge, Tor C., Dann, Sara M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291369/
https://ncbi.nlm.nih.gov/pubmed/30099125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.anaerobe.2018.07.011
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