Effects of intravenous AICAR (5-aminoimidazole-4-carboximide riboside) administration on insulin signaling and resistance in premature baboons, Papio sp.

Premature baboons exhibit peripheral insulin resistance and impaired insulin signaling. 5’ AMP-activated protein kinase (AMPK) activation improves insulin sensitivity by enhancing glucose uptake (via increased glucose transporter type 4 [GLUT4] translocation and activation of the extracellular signa...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Blanco, Cynthia L., Gastaldelli, Amalia, Anzueto, Diana G., Winter, Lauryn A., Seidner, Steven R., McCurnin, Donald C., Liang, Hanyu, Javors, Martin A., DeFronzo, Ralph A., Musi, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6291136/
https://ncbi.nlm.nih.gov/pubmed/30540820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0208757
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