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Lack of Vitamin D Receptor Leads to Hyperfunction of Claudin-2 in Intestinal Inflammatory Responses

BACKGROUND: Vitamin D3 and vitamin D receptor (VDR) are involved in the pathogenesis of inflammatory bowel disease (IBD) and bacterial infection. Claudin-2 is a junction protein that mediates paracellular water transport in epithelia. Elevation of Claudin-2 is associated with active IBD. However, VD...

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Detalhes bibliográficos
Publicado no:Inflamm Bowel Dis
Main Authors: Zhang, Yong-guo, Lu, Rong, Xia, Yinglin, Zhou, David, Petrof, Elaine, Claud, Erika C, Sun, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290786/
https://ncbi.nlm.nih.gov/pubmed/30289450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ibd/izy292
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