FOXM1 modulates 5-fluorouracil sensitivity in cholangiocarcinoma through thymidylate synthase (TYMS): implications of FOXM1–TYMS axis uncoupling in 5-FU resistance

Fluorouracil (5-FU) is the first-line chemotherapeutic drug for cholangiocarcinoma (CCA), but its efficacy has been compromised by the development of resistance. Development of 5-FU resistance is associated with elevated expression of its cellular target, thymidylate synthase (TYMS). E2F1 transcript...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Intuyod, Kitti, Saavedra-García, Paula, Zona, Stefania, Lai, Chun-Fui, Jiramongkol, Yannasittha, Vaeteewoottacharn, Kulthida, Pairojkul, Chawalit, Yao, Shang, Yong, Jay-Sze, Trakansuebkul, Sasanan, Waraasawapati, Sakda, Luvira, Vor, Wongkham, Sopit, Pinlaor, Somchai, Lam, Eric W.-F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290025/
https://ncbi.nlm.nih.gov/pubmed/30538221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1235-0
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