Attenuation of CD47-SIRPα Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis()()

The involvement of chronic inflammation in cholangiocarcinoma (CCA) progression is well established. Cluster of differentiation 47 (CD47) is mutually expressed in various cancers and serves as a protective signal for phagocytic elimination. CD47 signaling blockage is a recent treatment strategy; how...

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Veröffentlicht in:Transl Oncol
Hauptverfasser: Vaeteewoottacharn, Kulthida, Kariya, Ryusho, Pothipan, Phattarin, Fujikawa, Sawako, Pairojkul, Chawalit, Waraasawapati, Sakda, Kuwahara, Kazuhiko, Wongkham, Chaisiri, Wongkham, Sopit, Okada, Seiji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2018
Schlagworte:
Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231245/
https://ncbi.nlm.nih.gov/pubmed/30415063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2018.10.007
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