Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis

The high global burden of over one million annual lethal fungal infections reflects a lack of protective vaccines, late diagnosis and inadequate chemotherapy. Here, we have generated a unique set of fully human anti-Candida monoclonal antibodies (mAbs) with diagnostic and therapeutic potential by ex...

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Vydáno v:Nat Commun
Hlavní autoři: Rudkin, Fiona M., Raziunaite, Ingrida, Workman, Hillary, Essono, Sosthene, Belmonte, Rodrigo, MacCallum, Donna M., Johnson, Elizabeth M., Silva, Lisete M., Palma, Angelina S., Feizi, Ten, Jensen, Allan, Erwig, Lars P., Gow, Neil A. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6290022/
https://ncbi.nlm.nih.gov/pubmed/30538246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07738-1
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