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Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro

Cryptotanshinone (CT) is the main active component in the root of Salvia miltiorrhiza Bunge (SMB) that displays antibacterial, anti-inflammatory and anticancer activities. In this study, we characterized phase I and phase II metabolism of CT in human liver microsomes in vitro and identified the meta...

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Détails bibliographiques
Publié dans:Acta Pharmacol Sin
Auteurs principaux: Zeng, Jin, Fan, Yu-juan, Tan, Bo, Su, Hui-zong, Li, Yue, Zhang, Lin-lin, Jiang, Jian, Qiu, Fu-rong
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289345/
https://ncbi.nlm.nih.gov/pubmed/29417949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.144
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