Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

Non-alcoholic fatty liver disease (NAFLD) is a clinical syndrome characterized by hepatic steatosis. NAFLD is closely linked to obesity, insulin resistance and dyslipidemia. AMP-activated protein kinase (AMPK) functions as an energy sensor and plays a central role in regulating lipid metabolism. In...

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Udgivet i:Acta Pharmacol Sin
Main Authors: Zhang, Mei, Xie, Zhi-fu, Zhang, Run-tao, Chen, Da-kai, Gu, Min, Cui, Shi-chao, Zhang, Yang-ming, Zhang, Xin-wen, Yu, Yan-yan, Li, Jia, Nan, Fa-jun, Li, Jing-ya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289324/
https://ncbi.nlm.nih.gov/pubmed/29795358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2017.186
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