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More end resection is not merrier
Unrestrained 53BP1 activity causes fusions of dysfunctional telomeres and embryonic lethality associated with misrepair of DNA double-strand breaks in BRCA1-deficient mice. However, the physiological role of 53BP1 remains unclear, because it presumably did not evolve to carry out these pathological...
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| Udgivet i: | Nat Struct Mol Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6289258/ https://ncbi.nlm.nih.gov/pubmed/27487392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3274 |
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