Somatic Mutations Reveal Lineage Relationships and Age-Related Mutagenesis in Human Hematopoiesis

Mutation accumulation during life can contribute to hematopoietic dysfunction; however, the underlying dynamics are unknown. Somatic mutations in blood progenitors can provide insight into the rate and processes underlying this accumulation, as well as the developmental lineage tree and stem cell di...

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Опубликовано в: :Cell Rep
Главные авторы: Osorio, Fernando G., Rosendahl Huber, Axel, Oka, Rurika, Verheul, Mark, Patel, Sachin H., Hasaart, Karlijn, de la Fonteijne, Lisanne, Varela, Ignacio, Camargo, Fernando D., van Boxtel, Ruben
Формат: Artigo
Язык:Inglês
Опубликовано: Cell Press 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289083/
https://ncbi.nlm.nih.gov/pubmed/30485801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.11.014
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