Hypoxia-Inducible Factor 1-α (HIF-1α) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways

BACKGROUND: Hypoxia induces cell apoptosis in the uterosacral ligaments of patients with pelvic organ prolapse by upregulation of hypoxia-inducible factor-1α (HIF-1α). This study aimed to investigate the effects of HIF-1α on human uterosacral ligament fibroblasts (hUSLFs) following treatment with th...

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Vydáno v:Med Sci Monit
Hlavní autoři: Zhao, Xinrui, Liu, Lidong, Li, Rui, Wei, Xuan, Luan, Wenqing, Liu, Peishu, Zhao, Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: International Scientific Literature, Inc. 2018
Témata:
Lab/In Vitro Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6289032/
https://ncbi.nlm.nih.gov/pubmed/30504760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.913384
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