TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells

T cell activation is initiated upon ligand engagement of the T cell receptor (TCR) and costimulatory receptors. The CD28 molecule acts as a major costimulatory receptor in promoting full activation of naive T cells. However, despite extensive studies, why naive T cell activation requires concurrent...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Xia, Fan, Qian, Cheng-Rui, Xun, Zhou, Hamon, Yannick, Sartre, Anne-Marie, Formisano, Anthony, Mailfert, Sébastien, Phelipot, Marie-Claire, Billaudeau, Cyrille, Jaeger, Sébastien, Nunès, Jacques A., Guo, Xiao-Jun, He, Hai-Tao
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288997/
https://ncbi.nlm.nih.gov/pubmed/30564247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02864
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