Deletion of the murine ortholog of the 8q24 gene desert has anti-cancer effects in transgenic mammary cancer models

BACKGROUND: The gene desert on human chromosomal band 8q24 harbors multiple genetic variants associated with common cancers, including breast cancer. The locus, including the gene desert and its flanking genes, MYC, PVT1 and FAM84B, is also frequently amplified in human breast cancer. We generated a...

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Publicat a:BMC Cancer
Autors principals: Homer-Bouthiette, Collin, Zhao, Yang, Shunkwiler, Lauren B., Van Peel, Benjamine, Garrett-Mayer, Elizabeth, Baird, Rachael C., Rissman, Anna I., Guest, Stephen T., Ethier, Stephen P., John, Manorama C., Powers, Patricia A., Haag, Jill D., Gould, Michael N., Smits, Bart M. G.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288875/
https://ncbi.nlm.nih.gov/pubmed/30526553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-5109-8
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