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The 11-Kilodalton Nonstructural Protein of Human Parvovirus B19 Facilitates Viral DNA Replication by Interacting with Grb2 through Its Proline-Rich Motifs

Lytic infection of human parvovirus B19 (B19V) takes place exclusively in human erythroid progenitor cells of bone marrow and fetal liver, which disrupts erythropoiesis. During infection, B19V expresses three nonstructural proteins (NS1, 11-kDa, and 7.5-kDa) and two structural proteins (VP1 and VP2)...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Xu, Peng, Chen, Aaron Yun, Ganaie, Safder S., Cheng, Fang, Shen, Weiran, Wang, Xiaomei, Kleiboeker, Steve, Li, Yi, Qiu, Jianming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288338/
https://ncbi.nlm.nih.gov/pubmed/30282717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01464-18
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