High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors

Adeno-associated virus serotype 5 (AAV5) is being developed as a gene delivery vector for several diseases, including hemophilia and Huntington’s disease, and has a demonstrated efficient transduction in liver, lung, skeletal muscle, and the central nervous system. One limitation of AAV gene deliver...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Jose, Ariana, Mietzsch, Mario, Smith, J. Kennon, Kurian, Justin, Chipman, Paul, McKenna, Robert, Chiorini, John, Agbandje-McKenna, Mavis
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6288331/
https://ncbi.nlm.nih.gov/pubmed/30333169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01394-18
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