Adeno-Associated Virus Serotype 1 (AAV1)- and AAV5-Antibody Complex Structures Reveal Evolutionary Commonalities in Parvovirus Antigenic Reactivity

The clinical utility of the adeno-associated virus (AAV) gene delivery system has been validated by the regulatory approval of an AAV serotype 1 (AAV1) vector for the treatment of lipoprotein lipase deficiency. However, neutralization from preexisting antibodies is detrimental to AAV transduction ef...

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Udgivet i:J Virol
Main Authors: Tseng, Yu-Shan, Gurda, Brittney L., Chipman, Paul, McKenna, Robert, Afione, Sandra, Chiorini, John A., Muzyczka, Nicholas, Olson, Norman H., Baker, Timothy S., Kleinschmidt, Jürgen, Agbandje-McKenna, Mavis
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300747/
https://ncbi.nlm.nih.gov/pubmed/25410874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02710-14
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