Structural Fingerprinting of Protein Aggregates by Dynamic Nuclear Polarization-Enhanced Solid-State NMR at Natural Isotopic Abundance

[Image: see text] A pathological hallmark of Huntington’s disease (HD) is the formation of neuronal protein deposits containing mutant huntingtin fragments with expanded polyglutamine (polyQ) domains. Prior studies have shown the strengths of solid-state NMR (ssNMR) to probe the atomic structure of...

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Publicado en:J Am Chem Soc
Main Authors: Smith, Adam N., Märker, Katharina, Piretra, Talia, Boatz, Jennifer C., Matlahov, Irina, Kodali, Ravindra, Hediger, Sabine, van der Wel, Patrick C. A., De Paëpe, Gaël
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2018
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287890/
https://ncbi.nlm.nih.gov/pubmed/30339373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b09002
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