Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury

Early reperfusion of ischemic cardiac tissue increases inflammatory cell infiltration which contributes to cardiomyocyte death and loss of cardiac function, referred to as ischemia/reperfusion (IR) injury. Neutrophil- and mast cell-derived proteases, cathepsin G (Cat.G) and chymase, are released ear...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Basic Res Cardiol
Prif Awduron: Hooshdaran, Bahman, Kolpakov, Mikhail A., Guo, Xinji, Miller, Sonni A., Wang, Tao, Tilley, Douglas G., Rafiq, Khadija, Sabri, Abdelkarim
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287604/
https://ncbi.nlm.nih.gov/pubmed/28913553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-017-0652-z
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