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Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury

Early reperfusion of ischemic cardiac tissue increases inflammatory cell infiltration which contributes to cardiomyocyte death and loss of cardiac function, referred to as ischemia/reperfusion (IR) injury. Neutrophil- and mast cell-derived proteases, cathepsin G (Cat.G) and chymase, are released ear...

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: Hooshdaran, Bahman, Kolpakov, Mikhail A., Guo, Xinji, Miller, Sonni A., Wang, Tao, Tilley, Douglas G., Rafiq, Khadija, Sabri, Abdelkarim
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287604/
https://ncbi.nlm.nih.gov/pubmed/28913553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-017-0652-z
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