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Dual inhibition of cathepsin G and chymase reduces myocyte death and improves cardiac remodeling after myocardial ischemia reperfusion injury

Early reperfusion of ischemic cardiac tissue increases inflammatory cell infiltration which contributes to cardiomyocyte death and loss of cardiac function, referred to as ischemia/reperfusion (IR) injury. Neutrophil- and mast cell-derived proteases, cathepsin G (Cat.G) and chymase, are released ear...

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Bibliografiske detaljer
Udgivet i:Basic Res Cardiol
Main Authors: Hooshdaran, Bahman, Kolpakov, Mikhail A., Guo, Xinji, Miller, Sonni A., Wang, Tao, Tilley, Douglas G., Rafiq, Khadija, Sabri, Abdelkarim
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287604/
https://ncbi.nlm.nih.gov/pubmed/28913553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-017-0652-z
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