Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice

Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventions in the process of NASH/fibrosis. We investigate...

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Detalhes bibliográficos
Publicado no:Hepatol Commun
Main Authors: Morrison, Martine C., Verschuren, Lars, Salic, Kanita, Verheij, Joanne, Menke, Aswin, Wielinga, Peter Y., Iruarrizaga‐Lejarreta, Marta, Gole, Laurent, Yu, Wei‐Miao, Turner, Scott, Caspers, Martien P.M., Martínez‐Arranz, Ibon, Pieterman, Elsbet, Stoop, Reinout, van Koppen, Arianne, van den Hoek, Anita M., Mato, José M., Hanemaaijer, Roeland, Alonso, Cristina, Kleemann, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287481/
https://ncbi.nlm.nih.gov/pubmed/30556039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1270
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