Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice

Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventions in the process of NASH/fibrosis. We investigate...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Hepatol Commun
Päätekijät: Morrison, Martine C., Verschuren, Lars, Salic, Kanita, Verheij, Joanne, Menke, Aswin, Wielinga, Peter Y., Iruarrizaga‐Lejarreta, Marta, Gole, Laurent, Yu, Wei‐Miao, Turner, Scott, Caspers, Martien P.M., Martínez‐Arranz, Ibon, Pieterman, Elsbet, Stoop, Reinout, van Koppen, Arianne, van den Hoek, Anita M., Mato, José M., Hanemaaijer, Roeland, Alonso, Cristina, Kleemann, Robert
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: John Wiley and Sons Inc. 2018
Aiheet:
Original Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287481/
https://ncbi.nlm.nih.gov/pubmed/30556039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1270
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