Obeticholic Acid Modulates Serum Metabolites and Gene Signatures Characteristic of Human NASH and Attenuates Inflammation and Fibrosis Progression in Ldlr‐/‐.Leiden Mice

Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventions in the process of NASH/fibrosis. We investigate...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Hepatol Commun
Egile Nagusiak: Morrison, Martine C., Verschuren, Lars, Salic, Kanita, Verheij, Joanne, Menke, Aswin, Wielinga, Peter Y., Iruarrizaga‐Lejarreta, Marta, Gole, Laurent, Yu, Wei‐Miao, Turner, Scott, Caspers, Martien P.M., Martínez‐Arranz, Ibon, Pieterman, Elsbet, Stoop, Reinout, van Koppen, Arianne, van den Hoek, Anita M., Mato, José M., Hanemaaijer, Roeland, Alonso, Cristina, Kleemann, Robert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Original Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287481/
https://ncbi.nlm.nih.gov/pubmed/30556039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1270
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