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How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications

The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in serrated pathway tumourigenesis, and the BRAF V600E has been commonly associated with the CpG island methylator phenotype, mic...

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Dettagli Bibliografici
Pubblicato in:Gastroenterol Res Pract
Autori principali: Bond, Catherine E., Whitehall, Vicki L. J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6287148/
https://ncbi.nlm.nih.gov/pubmed/30598662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/9250757
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