Regulation of invariant NKT cell development and function by a 0.14 Mbp locus on chromosome 1: a possible role for Fcgr3

Invariant NKT (iNKT) cells are tissue-resident innate-like T cells critical to the host immune response. We previously identified a 6.6 Mbp region on chromosome 1 as a major regulator of iNKT cell number and function in C57BL/6 and 129X1/SvJ mice. Here, we fine-mapped this locus by assessing the iNK...

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Veröffentlicht in:Genes Immun
Hauptverfasser: DeVault, Victoria L., Malagic, Murisa, Mei, Linda, Dienz, Oliver, Lilley, Graham W. J., Benoit, Patrick, Mistri, Somen K., Musial, Shawn C., Ather, Jennifer L., Poynter, Matthew E., Boyson, Jonathan E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6286708/
https://ncbi.nlm.nih.gov/pubmed/29880961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41435-018-0031-2
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