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Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1
During drug development, tissue samples serve as indicators of disease activity and pharmacodynamic responses. Reliable non-invasive measures of drug target engagement will facilitate identification of promising new treatments. Here we develop and validate a novel bi-transgenic mouse model of myoton...
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| Publicat a: | Nat Commun |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6286378/ https://ncbi.nlm.nih.gov/pubmed/30531949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07517-y |
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