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Analysis of extracellular mRNA in human urine reveals splice variant biomarkers of muscular dystrophies

Urine contains extracellular RNA (exRNA) markers of urogenital cancers. However, the capacity of genetic material in urine to identify systemic diseases is unknown. Here we describe exRNA splice products in human urine as a source of biomarkers for the two most common forms of muscular dystrophies,...

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Vydáno v:Nat Commun
Hlavní autoři: Antoury, Layal, Hu, Ningyan, Balaj, Leonora, Das, Sudeshna, Georghiou, Sofia, Darras, Basil, Clark, Tim, Breakefield, Xandra O., Wheeler, Thurman M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6156576/
https://ncbi.nlm.nih.gov/pubmed/30254196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06206-0
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